Scientists discover how a protein finds its way

Apr. 29, 2013 ? Proteins, the workhorses of the body, can have more than one function, but they often need to be very specific in their action or they create cellular havoc, possibly leading to disease.

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have uncovered how an enzyme co-factor can bestow specificity on a class of proteins with otherwise nonspecific biochemical activity.

The protein in question helps in the assembly of ribosomes, large macromolecular machines that are critical to protein production and cell growth. This new discovery expands scientists' view of the role of co-factors and suggests such co-factors could be used to modify the activity of related proteins and their role in disease.

"In ribosome production, you need to do things very specifically," said TSRI Associate Professor Katrin Karbstein, who led the study. "Adding a co-factor like Rrp5 forces these enzymes to be specific in their actions. The obvious possibility is that if you could manipulate the co-factor, you could alter protein activity, which could prove to be tremendously important."

The new study, which is being published the week of April 29, 2013, in the online Early Edition of the Proceedings of the National Academy of Sciences, sheds light on proteins called DEAD-box proteins, a provocative title actually derived from their amino acid sequence. These proteins regulate all aspects of gene expression and RNA metabolism, particularly in the production of ribosomes, and are involved in cell metabolism. The link between defects in ribosome assembly and cancer and between DEAD-box proteins and cancer is well documented.

The findings show that the DEAD-box protein Rok1, needed in the production of a small ribosomal subunit, recognizes the RNA backbone, the basic structural framework of nucleic acids. The co-factor Rrp5 then gives Rok1 the ability to target a specific RNA sequence by modulating the structure of Rok1.

"Despite extensive efforts, the roles of these DEAD-box proteins in the assembly of the two ribosomal subunits remain largely unknown," Karbstein said. "Our study suggests that the solution may be to identify their cofactors first."

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The above story is reprinted from materials provided by Scripps Research Institute.

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Journal Reference:

1. Crystal L. Young, Sohail Khoshnevis, and Katrin Karbstein. Cofactor-dependent specificity of a DEAD-box protein. PNAS, 2013 DOI: 10.1073/pnas.1302577110

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/xmv1NTIqvrI/130429175906.htm

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Florida teenager's shooter faces deadline in court

By Barbara Liston

ORLANDO (Reuters) - Prosecutors in Florida want George Zimmerman to state publicly at a court hearing on Tuesday whether he will pursue his immunity defense in the 2012 shooting death of teenager Trayvon Martin on the basis of the state's "Stand Your Ground" law, or waive his right to use it.

Prosecutors asked Judge Debra Nelson in a motion to remind Zimmerman "that should defendant in fact wish to waive any pre-trial immunity challenge under this statute, he may not attempt to do so later, particularly once trial has commenced."

Zimmerman will attend Tuesday's hearing, according to his lawyer, Mark O'Mara. However, O'Mara told Reuters he hadn't decided what he will do if the judge tries to question his client.

"I know the state would like to have that information, it seems. I don't feel compelled to advise anybody of my strategy in this case," O'Mara said.

Zimmerman goes on trial June 10 on a second-degree murder charge for shooting Martin after prosecutors say he profiled and confronted the unarmed black teenager, despite a police dispatcher instructing him not to do so.

Zimmerman, 29, was a neighborhood watch volunteer at the time and Martin was walking back to a town home in the gated community in Sanford, Florida, with snacks to eat while watching a televised basketball game in February last year.

O'Mara has talked publicly about pursuing immunity for Zimmerman under Florida's controversial "Stand Your Ground" statute, which bars prosecution of someone who is in fear of his life and shoots rather than retreats. O'Mara canceled a scheduled hearing earlier this month to make the case, but told Reuters he believes he has the right to raise the immunity defense at any time during the trial.

"If you can convince someone, a judge, by preponderance of evidence that you acted in self defense, then you're immune, and that can happen however it happens," O'Mara said.

Prosecutors want to pin Zimmerman down on the record over waiving his right to pursue immunity in order to pre-empt the possibility that he might try to revive it after trial if he is found guilty, according to the motion. O'Mara said it would be difficult to raise the issue post-conviction.

Nelson also will hear a defense request to unseal a settlement between Martin's parents and the homeowner's association at The Retreat at Twin Lakes subdivision where Martin was killed.

The association's insurance company at one point offered its policy limit of $1 million to the family, according to correspondence between the insurance company and association attached to the motion. The defense argues that the jury should be able to consider the financial interest of potential witnesses in the case.

(Editing by David Adams and Christopher Wilson)

Source: http://news.yahoo.com/florida-teenagers-shooter-faces-deadline-court-110517464.html

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FDA will investigate added caffeine in foods

This product image provided by the Wm. Wrigley Jr. Company shows packaging for Alert Energy Caffeine Gum. (AP Photo/Wm. Wrigley Jr. Company)

This product image provided by the Wm. Wrigley Jr. Company shows packaging for Alert Energy Caffeine Gum. (AP Photo/Wm. Wrigley Jr. Company)

This product image provided by the Wm. Wrigley Jr. Company shows the back of packaging showing the nutritional facts for Alert Energy Caffeine Gum. (AP Photo/Wm. Wrigley Jr. Company)

WASHINGTON (AP) ? Looking for a new way to get that jolt of caffeine energy? Food companies are betting snacks like potato chips, jelly beans and gum with a caffeinated kick could be just the answer.

The Food and Drug Administration is closely watching the marketing of these foods and wants to know more about their safety.

The FDA said Monday it will look at the foods' effects on children in response to a caffeinated gum introduced this week by Wrigley. Alert Energy Gum promises "the right energy, right now."

The agency is already investigating the safety of energy drinks and energy shots, prompted by consumer reports of illness and death.

Michael Taylor, FDA's deputy commissioner of foods, said Monday that the only time FDA explicitly approved the added use of caffeine in a food or drink was in the 1950s for colas. The current proliferation of caffeine added to foods is "beyond anything FDA envisioned," Taylor said.

"It is disturbing," Taylor said in an interview with The Associated Press. "We're concerned about whether they have been adequately evaluated."

Taylor said the agency will look at the potential impact these "new and easy sources" of caffeine will have on children's health and will take action if necessary. He said that he and other FDA officials have held meetings with some of the large food companies that have ventured into caffeinated products, including Mars Inc., of which Wrigley is a subsidiary.

Wrigley and other companies adding caffeine to their products have labeled them as for adult use only. A spokeswoman for Wrigley, Denise M. Young, said the gum is for "adults who are looking for foods with caffeine for energy" and each piece contains about 40 milligrams, or the equivalent amount found in half a cup of coffee. She said the company will work with FDA.

"Millions of Americans consume caffeine responsibly and in moderation as part of their daily routines," Young said.

Food manufacturers have added caffeine to candy, nuts and other snack foods in recent years. Jelly Belly "Extreme Sport Beans," for example, have 50 mg of caffeine in each 100-calorie pack, while Arma Energy Snx markets trail mix, chips and other products that have caffeine.

Critics say it's not enough for the companies to say they are marketing the products to adults when the caffeine is added to items like candy that are attractive to children. Major medical associations have warned that too much caffeine can be dangerous for children, who have less ability to process the stimulant than adults. The American Academy of Pediatrics says caffeine has been linked to harmful effects on young people's developing neurologic and cardiovascular systems.

"Could caffeinated macaroni and cheese or breakfast cereal be next?" said Michael Jacobson, director of the Center for Science in the Public Interest, which wrote the FDA a letter concerned about the number of foods with added caffeine last year. "One serving of any of these foods isn't likely to harm anyone. The concern is that it will be increasingly easy to consume caffeine throughout the day, sometimes unwittingly, as companies add caffeine to candies, nuts, snacks and other foods. "

Taylor said the agency would look at the added caffeine in its totality ? while one product might not cause adverse effects, the increasing number of caffeinated products on the market, including drinks, could mean more adverse health effects for children.

Last November, the FDA said it had received 92 reports over four years that cited illnesses, hospitalizations and deaths after consumption of an energy shot marketed as 5-Hour Energy. The FDA said it had also received reports that cited the highly caffeinated Monster Energy Drink in several deaths.

Agency officials said then that the reports to the FDA from consumers, doctors and others don't necessarily prove that the drinks caused the deaths or injuries but said they were investigating each one. In February, FDA Commissioner Margaret Hamburg again stressed that reports to the agency of adverse events related to energy drinks did not necessarily suggest a causal effect.

FDA officials said they would take action if they could link the deaths to consumption of the energy drinks, including forcing the companies to take the products off the market.

In 2010, the agency forced manufacturers of alcoholic caffeinated beverages to cease production of those drinks. The agency said the combination of caffeine and alcohol could lead to a "wide-awake drunk" and has led to alcohol poisoning, car accidents and assaults.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/bbd825583c8542898e6fa7d440b9febc/Article_2013-04-30-FDA-Added%20Caffeine/id-f3806041547a4aad9f47c58abbb7a6da

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What to Do (If Anything) About a Cluttered OS X Desktop

For better or worse, my digital file organization and storage strategy mimics what you?d find on my desk in real life: clutter. Luckily, technology has made it such that it doesn?t really matter if my MacBook Pro?s desktop is littered ...

Source: http://feedproxy.google.com/~r/GearFactor/~3/29YYezxouZE/

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Denise Richards Skinny Rumors Addressed, Debunked by Actress

Source: http://www.thehollywoodgossip.com/2013/04/denise-richards-skinny-rumors-addressed-debunked-by-actress/

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NATO: 4 service members killed in place crash

KABUL, Afghanistan (AP) ? A plane crashed in southern Afghanistan on Saturday, killing four international service members, NATO said.

Initial reporting indicated there was no enemy activity in the area at the time, but coalition personnel secured the site and the cause of the crash was being investigated, NATO said.

The brief statement did not identify the nationalities of the victims, or say where the plane went down.

However, Mohammad Jan Rasoulyar, deputy governor of the southern province of Zabul, said an aircraft belonging to foreign forces crashed Saturday afternoon in Shah Joy district. He said the site had been surrounded by international forces.

Source: http://news.yahoo.com/nato-4-members-killed-place-crash-165245206.html

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HBT: Youk shakes off back injury, starts for Yanks

Kevin Youkilis is back in the Yankees? lineup this afternoon for the first time in a week, reports Dan Barbarisi of the Wall Street Journal.

Youkilis missed his sixth straight game yesterday due to lower back tightness, which led to a potential stint on the disabled list, but he was cleared to return after he made it through batting practice this afternoon without incident. He?s starting at first base this afternoon against the Blue Jays while Jayson Nix is playing third.

Youkilis is hitting .259 (17-for-61) with two homers, seven RBI and a .796 OPS through 16 games this season. Due to a wide variety of injuries, the 34-year-old has averaged just 120 games played over the past four seasons.

Source: http://hardballtalk.nbcsports.com/2013/04/27/kevin-youkilis-returns-to-yankees-lineup-after-missing-six-games-with-back-injury/related/

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Weekend cooking ? fried squash blossoms (Americablog)

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Syria rejects US, UK chemical arms claims | Morocco World News

DAMASCUS, April 27, 2013 (AFP)

Syria dismissed as a ?barefaced lie? on Saturday American and British claims it may have used chemical arms, as staunch ally Russia warned against using such fears to intervene militarily in the strife-torn country.

?First of all, I want to confirm that statements by the US secretary of state and British government are inconsistent with reality and a barefaced lie,? Syrian Information Minister Omran al-Zohbi said in an interview published on the Kremlin-funded Russia Today?s website.

?I want to stress one more time that Syria would never use it ? not only because of its adherence to the international law and rules of leading war, but because of humanitarian and moral issues,? Zohbi said.

UN chief Ban Ki-moon has called on Damascus to approve a UN mission of inspectors to probe the alleged use of chemical weapons in the spiralling conflict that erupted in March 2011.

But Zohbi told Russia Today that Syria could not trust UN inspectors from Britain and the United States.

?We also do not trust their qualifications. Their aim is to juggle with facts,? he said, adding that Syria would accept Russian inspectors.

?We won?t mind if Russians would be among the experts; quite the contrary, we only welcome this idea. We are quite sure in their high qualification and ability to clearly see into such matters,? he was quoted as saying.

Along with China, Russia has blocked several UN Security Council draft resolutions threatening sanctions against President Bashar al-Assad?s regime.

US President Barack Obama warned Syria on Friday that using chemical weapons would be a ?game changer?, after the US, Israel and Britain cited signs that Assad?s regime has used the deadly agent sarin.

But Obama said Washington must act prudently and establish exactly if, how and when such arms may have been used, promising a ?vigorous? US and international probe into the latest reports.

Russia warned against using these reports for military intervention.

?We must check the information immediately and in conformity with international criteria, and not use it to achieve other objectives. It must not be a pretext for an intervention in Syria,? deputy foreign minister and Middle East envoy Mikhail Bogdanov said in Beirut.

Zohbi linked the chemical arms accusations to what he said was the recent military success of regime forces.

?I want to give you joy: there are qualitative changes on the battlefields. The uproar from the Americans that has arisen in the last 48 hours is due to this,? he was quoted as saying by the RIA Novosti news agency.

Zohbi on Friday said at a news conference in comments published by the Interfax news agency that chemical weapons were used by rebels and originated in Turkey.

The Syrian opposition has stepped up pressure by urging the UN Security Council to take immediate steps, possibly even by imposing a no-fly zone on Syria.

And British Prime Minister David Cameron said the growing evidence that Assad had turned chemical agents on his own people was ?extremely serious?.

Fighting continued unabated on Saturday, with at least 10 people killed in shelling on Douma northeast of Damascus, the Syrian Observatory for Human Rights said.

On Friday, at least 127 people were killed across the country, it said.? Analysts said Syria?s neighbours face a growing risk of the conflict spilling across their region as Assad turns to ever more desperate acts to halt rebels.

They said Lebanon and Jordan will be the most vulnerable if the conflict spreads, while Iraq will also be affected along with Israel and Turkey.

?It is a very vulnerable region and there is a risk of escalation,? said Anthony Skinner of British risk consultancy Maplecroft.

Iraqi Prime Minister Nuri al-Maliki alluded to Syria on Saturday, saying sectarian strife growing in his own country ?came back to Iraq because it began in another place in this region.?

Senior Egyptian officials, meanwhile, visited Iran on Saturday to further a proposal by Cairo for an Islamic quartet of Egypt, Turkey, Saudi Arabia and Iran that would help to resolve the Syrian conflict, the Egyptian presidency said.

Turkey, Egypt and Saudi Arabia support the mostly Sunni rebels in Syria, while Shiite Iran backs Assad?s minority-led Alawite regime.

Source: http://www.moroccoworldnews.com/2013/04/88731/syria-rejects-us-uk-chemical-arms-claims/

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The Right Way to Care for Your Pocket Knife

You may know how to care for a kitchen knife, but when's the last time you paid your simple pocket knife the attention it deserves? Instructables user kennethisme has a great tutorial on how to care for your average folding pocket knife, from cleaning the blade to lubricating the body.

It's something that a lot of people overlook, especially if your primary use for a pocket knife is opening packages, mail, and occasionally cutting zip ties and other tough plastic bits. Just like a kitchen knife, the dirtier it gets the more dangerous it is, so keeping it in good condition is important. Kennethisme scrubs the blade down with warm, soapy water and an old toothbrush, and then moves on to picking the right lubricant to keep the hinge, lock, and other moving parts well oiled. He suggests a petroleum-based wet lubricant, as opposed to a spray-on dry lubricant that will attract lint or dust. Similarly, he points out that you should use a food-grade lubricant if you plan to use your pocket knife in any food preparation.

Hit the link below for the whole guide and a few more tips, including specific lubricant suggestions. He doesn't get into keeping a pocket knife sharp, but the principles there are similar to other, previously mentioned kitchen skills. Unfortunately taking proper care of a pocket knife is something many of us often forget, and the guide makes it easy.

Pocket Knife Maintenance: Cleaning and Lubricating | Instructables

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/ldVsMZvoDU4/the-right-way-to-care-for-your-pocket-knife-481664338

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Harvick wins Richmond after 2-lap overtime sprint

RICHMOND, Va. (AP) ? When the dust settled at Richmond, 'Ol Happy Harvick was the only driver smiling.

Kevin Harvick plowed through traffic on the final restart, driving from seventh to Victory Lane in a two-lap overtime sprint to the finish Saturday night at Richmond International Raceway. He did it with one of those head-scratching "Where did he come from?" drives in which everyone was just hanging on.

"Just shifted gears, hit the pedal and hoped for the best," Harvick said. "They all went high and I went low. The seas kind of parted there. They didn't get a very good restart, and my car launched.

"I was able to take it three-wide, those guys all drove it in hard, and I was able to get by the next two. I only had one to go by the time I got to the backstretch."

It was Harvick's first Sprint Cup win of the season ? he opened the year with a win in the exhibition Sprint Unlimited at Daytona ? and his 20th career victory. It put Chevrolet and Richard Childress Racing in Victory Lane, snapping a two-race winning streak by Joe Gibbs Racing.

"That was vintage Kevin Harvick right there," crew chief Gil Martin said.

Juan Pablo Montoya was trying to hold off Harvick for his first win since 2010 when the caution came out with four laps remaining.

"I was like, 'Really? Really?'" Montoya said about the caution. He pounded his fist on the steering wheel when the yellow flag waved.

Montoya left the decision to pit or stay out to crew chief Chris Heroy, who gamely tried to calm the driver and convince him he could still win the race. He brought Montoya down pit road, a decision most of the field followed as everyone traded track position for tires.

Both Montoya and Harvick took four tires, which put them sixth and seventh on the final restart. Harvick teammate Jeff Burton was the leader after Burton, Jamie McMurray and AJ Allmendinger didn't pit and stayed on the track.

When the race resumed, the first three cars on old tires couldn't hold off traffic, creating mayhem through the field. Harvick rocketed his way through the pack, dragging Clint Bowyer and Joey Logano with him.

Bowyer wound up second, Logano third and Montoya had to settle for fourth.

Montoya, who is off to a horrific start to the season with six finishes of 20th or worse in the first eight races, was comforted with his first top-10 finish of the season.

"That is what we needed," he said. "I felt like last week we had a top-five car as well, but not quite a car to win. I think this weekend, we came here and tested, and the guys did an amazing job, and we had a good car all weekend."

Tony Stewart restarted in fifth, but was bumped out of the way by Kurt Busch and faded to 18th. Stewart angrily traded bumps with Busch on the cool-down lap, even trying to force him into the wall, before the two drivers headed to the garage. Once back at their haulers Stewart and Busch shouted at each other over crew members, with Busch claiming the final two laps "were a free-for-all."

"We were hoping to be on the right sequence at the end," Busch said. "Some guys had older tires. Some guys had newer tires. We were in the mixed. A green-white-checkered at the end, it is just chaos. Cars are everywhere. People are beating and banging and shoving each other out of the way. It's pretty wild."

Burton wound up fifth to give RCR two cars in the top-five. Carl Edwards was sixth in the highest finishing Ford, and Matt Kenseth, who started from the pole and led a race-high 140 laps, was seventh for JGR.

Kenseth came into the race on the heels of stifling NASCAR sanctions after an illegal part was found in last week's race-winning engine. NASCAR essentially stripped Kenseth and JGR of everything but the trophy, but the team responded with another strong showing.

He felt he could have finished higher if not for the frantic final restart.

"Just being on the outside and (Busch) drove up through there and knocked my whole side off and put me in the marbles," Kenseth said. "Just two laps, everybody is going to go for it and go for every hole they've got."

Aric Almirola was eighth for his third consecutive top-10 finish, and Busch and Dale Earnhardt Jr. rounded out the top 10.

Source: http://news.yahoo.com/harvick-wins-richmond-2-lap-overtime-sprint-031958957.html

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Justin Bieber Shocks Fans With Snuggly Selena Gomez Pic

And this time, he doesn't delete the Instagram photo.
By Emilee Lindner

Source: http://www.mtv.com/news/articles/1706444/justin-bieber-selena-gomez-instagram-cuddle.jhtml

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Monkeys imitate local food norms, study finds

The maxim, 'When in Rome, do as the Romans do' also applies to non-human primates, as scientists discover that wild monkeys have an ability to imitate the social eating behavior of other groups of monkeys. ?

By Mai Ng?c Ch?u,?Contributor / April 26, 2013

Vervet monkeys eat bread on a lawn near some tourist bungalows in Kruger National Park, South Africa.

Melanie Stetson Freeman / The Christian Science Monitor.

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The tendency to adapt to cultural behaviors in a new place is not unique to us, a new study suggests.

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A study led by psychologists of the University of St Andrews in Scotland finds that vervet monkeys (Chlorocebus aethiops) in South Africa prefer food that those around them are eating.

The researchers dyed corn pink or blue and trained groups of monkeys to eat corn of one color and avoid the other. When young males migrated from one group to a group that preferred the opposite color, most of them immediately switched to the local preference.

Leading primate experts call this research?evidence of "cultural transmission"?in wild primates, which could also help to explain the evolution of our human desire to search for "local knowledge" when traveling to a new culture.

In a press release from St Andrews, noted primatologist?Frans de Waal?called the research "ione of the few successful field experiments on cultural transmission to date.? De Waal did not participate in the study.?

Carel van Schaik, an evolutionary anthropologist at the University of Zurich, was also impressed. "Culture was thought to be something only humans had? he told the New York Times. "If you define culture as socially transmitted knowledge, skills and information, it turns out we see some of that in animals. Now this experiment comes along and I must say it really blew me away.?

According to the study's?authors, the discovery demonstrates that social learning and cultural conformity play an important role in the behavior of animals as well as humans.?

"As the saying goes, 'When in Rome, do as the Romans do,'" said co-author Andrew Whiten in the St Andrews press release. "Our findings suggest that a willingness to conform to what all those around you are doing when you visit a different culture is a disposition share by other primates."?

The study was published on April 25 by the journal Science.

Whiten and his colleagues conducted field experiments at the Inkawu Vervet Project in the Mawana private game reserve in South Africa. At first, they induced conformity in four groups of wild vervet monkeys with 109 animals in total.

The team fed the first two groups of monkeys with a box of corn dyed blue and another dyed pink. The blue corn was soaked in bitter aloe leaves and to be made distasteful to the monkeys, so they soon ate only pink corn. For two other groups, pink corn was made bitter, and the monkeys learned to prefer blue corn. Once the monkeys were trained, the researchers stopped adding the aloe to the corn.?

Four months later, 27 infants were born. When they were able to eat solid food, the researchers supplied baby and adult monkeys with blue and pink corn. The adult animals stuck to their favorite color, and 26 of the infants ate only the corn the adult?monkeys liked.?

During the mating season, 10 male monkeys joined other groups that ate corn with a color different from the one their native group did. What surprised the researchers was that seven migrants quickly took up the locally-preferred corn, suggesting that they conformed to the cultural norm of their new group. With no higher ranking monkey present, the other two soon followed suit.

Researchers said the single monkey who continued to choose the same color as in his original group was perhaps taking the top rank in his new group, a factor that might explain his nonconformist behavior.

?The willingness of the immigrant males to adopt the local preference of their new groups surprised us all," said co-author Erica van de Waal, in the press release. "The copying behaviour of both the new, na?ve infants and the migrating males reveals the potency and importance of social learning in these wild primates, extending even to the conformity we know so well in humans.?

She said the study was?one of the very few successful controlled experiments in the wild, which "hints at a level of conformism most of us, until now, held not possible."

The cultural learning ability discovered in vervet monkeys is reminiscent of a well-known study of Japanese macaques?in the 1950s, in which one monkey was observed washing her food, a practice that spread throughout the troop and was passed on to subsequent generations. ?

Monkeys aren't the only animals observed transmitting cultural information. Another study conducted by a different group of scientists at the University of St Andrews found that whales learned feeding techniques?from their peers. Through analysis of a 27-year database on whale behavior collected in the Stellwagen Bank National Marine Sanctuary, the researchers find that?lobtail feeding had spread to 37 percent of the whale's population.?

Susan Perry, an anthropologist at the University of California, Los Angeles, finds the whale study to be "a highly convincing case for a foraging tradition in a cetacean."

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/yduyIDPJX_E/Monkeys-imitate-local-food-norms-study-finds

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Instant View: Amazon sustains growth, revenue up 22 percent

SAN FRANCISCO (Reuters) - Amazon.com Inc kept up a strong pace of growth in core retail and newer businesses like digital media, posting a 22 percent jump in revenue to $16.1 billion in the first quarter, while its earnings beat expectations.

Commentary:

KERRY RICE, ANALYST, NEEDHAM & CO

"Gross margin is definitely better than expected. That is something that investors are certainly keen on.

"Guidance was light, both top- and bottom-line. That certainly won't help the stock perform, although they have over the last several quarters exceeded expectations on the operating income side. So for the guidance, people are more concerned about revenue than operating income."

(Reporting By Malathi Nayak and Poornima Gupta)

Source: http://news.yahoo.com/instant-view-amazon-sustains-growth-revenue-22-percent-202758794--finance.html

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Futures head lower ahead of economic growth report

NEW YORK (AP) ? Futures are falling after a solid week of corporate earnings drove all major markets higher, as investors grow more cautious before the latest U.S. economic growth report is released.

Dow Jones industrial futures are down 35 points to 14,618. S&P futures have lost 4.9 points to 1,576.80. Nasdaq futures are down 9.75 points to 2,834.25.

Most economists believe that U.S. economic growth was reignited during the first three months of the year after coming to a standstill to end 2012.

Yet there is considerable apprehension about the effects of higher taxes and diminished government spending. Economists predict that the overall economy grew at an annual rate of 3.1 percent from January to March.

The Commerce Department releases the report at 8:30 a.m. Eastern on Friday.

Source: http://news.yahoo.com/futures-head-lower-ahead-economic-growth-report-114859079--finance.html

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How To Lose The Sequestration Fight (talking-points-memo)

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Politicians Will Only Roll Back Parts of the Sequester That Hurt Them, Naturally (Atlantic Politics Channel)

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House passes Senate plan to ease air traffic delays (reuters)

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Measles cases in south Wales outbreak climb to 942

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Measles cases in south Wales outbreak climb to 942
Figure for greater Swansea area rises by 56 as experts warn epidemic shows no sign of easingMeasles cases in south Wales have jumped by 56 in two days as experts warn the outbreak shows no sign of ending.

Source: TheGuardian
Posted on: Thursday, Apr 25, 2013, 11:26am
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Los And Lola Monroe's Baby Is A Taylor Gang Bad Boy

'He got the best of both worlds ... he got two strong families on either side,' Los tells MTV News of son Brixton Royal.
By Rob Markman

Source: http://www.mtv.com/news/articles/1706226/los-lola-monroe-baby.jhtml

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Today's White House correspondents are not lapdogs

But in the past, they certainly have been

"Why don't you leave him alone?" supporters of President Obama tweet me. "Give the man a break and stop being disrespectful."

"You're all just a bunch of suck-up lefties," opponents of President Obama tweet at me, referring, I presume, to the White House Press Corps. "Why don't you try asking a real question for a change?"

SEE MORE: Could the 2013 NFL draft be one of the weakest ever?

You can't please everyone. And someone is always going to be mad at the White House Press Corps. But it's all in eye of the beholder. And, as I'll explain, there have been times when both sides have been right.

Conservatives often like to say that White House reporters (who often work for big, conservative companies like News Corp., Time Warner, and Disney) are liberals who just pass along whatever they are spoonfed by Team Obama. In this view, it's all a big love fest between journalists and the president down the hall.

They ask why the "liberal media" ignored the Sept. 11 Benghazi attack that killed four Americans, including Ambassador Chris Stevens. Somehow these critics missed the 800+ articles that The Washington Post and New York Times alone have run on the story.

Also: If White House reporters are lapdogs, why does President Obama hold so few news conferences? If we are lapdogs, why doesn't Obama talk more to newspapers and TV networks accused of being "friendlies," like the Times or the Post or MSNBC??And if reporters are so eager to passively be spoonfed everything Obama says, why does he feel it necessary build his own massive network to get his point of view out?

If anything, Obama is press averse to an historic degree. "The way the president's availability to the press has shrunk in the last two years is a disgrace," ABC News White House reporter Ann Compton recently told Politico. Ann should know. She's been at the White House since Gerald Ford was president. "This is different from every president I covered. This White House goes to extreme lengths to keep the press away," she adds.

Today's White House Press Corp. is hardly a lapdog. But in the past, Beltway reporters have been cowed by presidents.?

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Franklin D. Roosevelt, who was paralyzed by polio, served 12 years as president, yet the FDR library in Hyde Park, N.Y., only has three photos of him in a wheelchair. "There was a gentlemen's understanding with the press," says the library's website, that photographs displaying FDR's disability were not published." Think that would happen today?

Similarly, as the Monica Lewinsky scandal showed, reporters today simply won't turn a blind eye to a philandering president. In the 1960s, the press corps did exactly that with John F. Kennedy. While in office, it's believed he slept with a woman who also slept with two Mafia bosses; it's also believed that another mistress was an East German spy. Think a White House reporter would ignore a bombshell like that today?

Of course, it's also true that journalists were obedient little lapdogs on matters far more serious than even Benghazi. After that other September 11 attack (you know, back in 2001), the White House leaned on the press corps big time. Attorney General John Ashcroft said questioning the Bush administration "only aids terrorists" and "gives ammunition to America's enemies," while Press Secretary Ari Fleischer warned that "all Americans... need to watch what they say, watch what they do."

In the run-up to the Iraq war from September 2002 to February 2003,?414 Iraq stories aired on the evening broadcasts of ABC, CBS and NBC News, according to media analyst Andrew Tyndall. More than 9 in 10 of them relied on Bush administration sourcing. Reporters did just 34 stories (8 percent) that required independent questioning of non-administration sources. And talk about not wanting to offend the White House: MSNBC fired its top-rated host, the super liberal Phil Donahue, because, as an internal memo said, Donahue's anti-administration views presented "a difficult public face for NBC in a time of war."

It gets worse still. In a news conference two weeks before the Iraq invasion, President Bush mentioned al Qaeda and the terrorist attacks of September 11 multiple times. No one challenged the connection Bush appeared to be making between al Qaeda and Iraq ? even though intelligence sources by then were publicly questioning the connection.

SEE MORE: What we don't know about Boston

That, ladies and gentlemen, is a lapdog press.

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Source: http://news.yahoo.com/todays-white-house-correspondents-not-lapdogs-102628988.html

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An Introduction To Complications: The Tourbillon

Editor's note: This is part three in a series of introductory pieces on watches from our friends at Hodinkee. You can read part one here and part two here. More »

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Wisconsin True Value: Outdoor Lighting and Decor for Your ...

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